Effects of Tamsulosin, an Α1-adrenergic Antagonist, and Tak- 802, a Novel Acetylcholinesterase Inhibitor, and Their Synergistic Effects on the Urodynamic Characteristics in a Guinea Pig Model of Functional Bladder Outlet Obstruction

Hypothesis / aims of study The efficacy of α1-adrenergic antagonists in the treatment of lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia (BPH) is generally attributable to improvement of the urodynamic characteristics and relief of bladder instability. While the latter effect has been partly confirmed in an animal model with partial bladder outlet obstruction (BOO), the former effect has not been well documented in experimental studies using animals, because no suitable animal model has yet been developed to assess the effects of α1-adrenergic antagonists on the urodynamic characteristics. In this study, we attempted to establish an animal model with functional BOO to model the dynamic component of BPH, and to evaluate the effects of tamsulosin, an α1-adrenergic antagonist, TAK-802, a novel acetylcholinesterase (AChE) inhibitor with some selectivity for muscarinic actions (1), and of both administered concomitantly on the urodynamic characteristics in this model.